化合物 TH588 hydrochloride T60984

Product Introduction
Bioactivity


英文名: TH588 hydrochloride

描述: TH588 hydrochlorid 是创新的 nudix 水解酶家族抑制剂，可选择性的高效结合并抑制MTH1 (NUDT1)，IC50值为 5 nM。

体外活性: TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC 50 s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM [1]. Cell Viability Assay [1] Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration: 2, 4, 6, 8, 10 μM Incubation Time: 7–10 days Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC 50 s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, respectively, but was less toxic to several primary or immortalized cells.

体内活性: TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model [1]. Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model) [1] Dosage: 30 mg/kg Administration: Subcutaneous injection (s.c.); once daily for 35 days Result: Reduced tumour growth in SW480 xenograft cancer model.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途