化合物ZINC12409120 T61122

Product Introduction
Bioactivity


英文名: ZINC12409120

描述: ZINC12409120 (R-4584) 是一种具有选择性的 ERK 抑制剂。ZINC12409120 对ERK具有抑制作用，IC50 为 5.0 μM。ZINC12409120 通过干扰 FGF23:α-Klotho 的相互作用而抑制 ERK 活性。

体外活性: ZINC12409120 (1 nM-0.1 mM; 5 h) inhibits ERK reporter activities mediated by FGF23 (1 μM), with an IC50 of 5 μM.[1] ZINC12409120 (10 μM; 5 h) specifically inhibits ERK activity mediated by FGF23:α-Klotho instead of EGF-mediated ERK activation and exhibits no inhibitory effect on EGFR tyrosine kinase or EGF/EGFR interaction.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (145.19 mM)


关键字: ZINC-12409120 | ZINC12409120 | ZINC 12409120 | R4584 | R 4584

相关产品: Urolithin B | 15-Methoxypinusolidic acid | EM127 | Notoginsenoside R1 | AMG PERK 44 | Dehydroeffusol | PERK-IN-2 | Astragaloside IV | BIX02189 | Pseudoginsenoside Rh2

相关库: Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compound Library

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