化合物 Opipramol T61376

Product Introduction
Bioactivity


英文名: Opipramol

描述: Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].

体外活性: Opipramol can potently interact with sigma recognition sites with a K i value of 50 nM [1]. Opipramol inhibit the uptake of [ 3 H] DA in crude synaptosomal preparations with an IC 50 value of 5.5 μM [1].

体内活性: Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo [2]. Animal Model: Sprague-Dawley rats (male, 150-l 80 g) [2] Dosage: 5-50 mg/kg Administration: Intraperitoneal injections Result: Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA. Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat. Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途