化合物 CHIKV-IN-3 T61675

Product Introduction
Bioactivity


英文名: CHIKV-IN-3

描述: CHIKV-IN-3 是一种有效的针对 CHIKV-122508和 CHIKV-6708的低通道抑制剂，其 EC50值分别为 1.55 和 0.14 μM。CHIKV-IN-3 作用于宿主细胞以干扰病毒复制。CHIKV-IN-3 表现出极小的细胞毒性 (CC50> 100 μM)。预防作用。

体外活性: CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 μM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC 50 of 1.55 μM and demonstrates low cytotoxicity ( CC 50 =129.6 μM) [1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 μM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: HeLa CCL2 cells, HeLa CCL2 cells infected with CHIKV-122508 Concentration: 0.1-100 μM Incubation Time: 24 hours Result: Inhibited the CHIKV replication with an EC 50 of 1.55 μM and demonstrated low cytotoxicity( CC 50 =129.6 μM)

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途