靛玉红 T6169

Product Introduction
Bioactivity


英文名: Indirubin

描述: Indirubin (Couroupitine B) 是一种具有抗炎症和抗癌活性的天然产物。

体外活性: Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin inhibits CDKs activity with IC50 of 2.2 - 10 μM resulting in cell cycle arrest in the G2/M phase. [1] Indirubin also inhibits GSK-3β with an IC50 of 0.6 μM, attenuating CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. [2] It also suppresses tumor necrosis factor (TNF)-induced NF-κB activation in a dose- and time-dependent manner. Indirubin also suppresses the NF-κB activation induced by various inflammatory agents and carcinogens. Indirubin blocks the phosphorylation and degradation of IκBα through the inhibition of activation of IκBα kinase and phosphorylation and nuclear translocation of p65. [3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 53 mg/mL (202.08 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: Inhibitor | Indirubin | inhibit | NSC-105327 | anticancer | Apoptosis | NSC105327

相关产品: Calycosin | Candesartan Cilexetil | Cucurbitacin IIb | BX-912 | 6-Azauridine | Pracinostat | RHPS4 | NU 7026 | (S)-(−)-Perillyl alcohol | Pemetrexed disodium hemipenta hydrate

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Kinase Inhibitor Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途