化合物ABBV-CLS-484 T61699
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 2489404-97-7 | ¥12,800.00 | 询底价 |
25 mg | 2489404-97-7 | ¥18,800.00 | 询底价 |
50 mg | 2489404-97-7 | ¥25,700.00 | 询底价 |
5 mg | 2489404-97-7 | ¥9,520.00 | 询底价 |
100 mg | 2489404-97-7 | ¥34,700.00 | 询底价 |
1 mg | 2489404-97-7 | ¥4,570.00 | 询底价 |
2 mg | 2489404-97-7 | ¥6,390.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Osunprotafib
描述: ABBV-CLS-484 (Osunprotafib) 是一种具有亚纳摩尔活性的有效的PTPN2抑制剂,具有抗肿瘤活性,可增强T细胞抗肿瘤免疫力。ABBV-CLS-484可用于治疗肿瘤、食管癌和消化系统疾病。
体外活性: ABBV-CLS-484 acts simultaneously on tumor cells and the host immune system, inducing unique transcriptional changes in myeloid and lymphocyte populations in the tumor microenvironment, enhancing the activation and effector functions of CD8+ T cells, while reducing T cell exhaustion and dysfunction. Expression of classical genes.[2]
体内活性: ABBV-CLS-484 promotes anti-tumor immunity as a single agent, and when combined with anti-PD-1, results in significant tumor regression, even in models that are resistant to anti-PD-1 treatment, such as 4T1 and EMT6.[3]
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 56.2 mg/mL (145.9 mM)
关键字: ABBV-CLS484 | AC-484 | ABBV-CLS 484
相关产品: Pentamidine isethionate | DA-3003-1 | Boehmenan | Tetramisole hydrochloride | PTP1B-IN-3 | Razuprotafib | NSC-87877 | Cyclosporine | CDC25B-IN-1 | CDC25B-IN-2
相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途