化合物 CDK4/6-IN-7 T61738

Product Introduction
Bioactivity


英文名: CDK4/6-IN-7

描述: CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].

体外活性: CDK4/6-IN-7 (compound 7c) (0.1-656.1 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC 50 of 0.92 μM [1]. Cell Proliferation Assay [1] Cell Line: MCF-7 cells Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 μM Incubation Time: 48 hours Result: Inhibited MCF-7 cells growth, with an IC 50 of 0.92 μM.

体内活性: CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice [1]. Animal Model: Female nude mice (5 weeks) bearing MCF-7 tumor [1] Dosage: 50 mg/kg Administration: Oral gavage once daily for 7 days Result: Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途