化合物UPF 1069 T6181

Product Introduction
Bioactivity


英文名: UPF 1069

描述: UPF 1069 是一种特异性PARP 抑制剂，对 PARP-1 和 PARP-2 的IC50值分别为 8 和 0.3 μM。

体外活性: UPF 1069 是一种选择性的 PARP2 抑制剂，其 IC50 值为0.3 μM，同时对 PARP1 的抑制作用较弱，IC50 值为8 μM。[1]

体内活性: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.9 mg/mL (100 mM)


关键字: UPF1069 | inhibit | PARP | Inhibitor | poly ADP ribose polymerase | UPF-1069 | UPF 1069

相关产品: PARP1/2/TNKS1/2-IN-1 | RBN-2397 | G007-LK | PJ34 | TIQ-A | PARP1-IN-16 | 4-amino-1,8-Naphthalimide | PARP10-IN-3 | PARP/PI3K-IN-1 | PARP1-IN-5 dihydrochloride 

相关库: Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | DNA Damage & Repair Compound Library | Anti-Cardiovascular Disease Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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