化合物 DN02 T61874

Product Introduction
Bioactivity


英文名: DN02

描述: DN02 is a highly potent and selective probe for the BRD8 bromodomain. It demonstrates a marked affinity for the BRD8(1) isoform with a Ki value of 32 nM, exhibiting a 30-fold greater affinity compared to BRD8(2) isoform with a Ki value greater than 1000 nM [1].

体外活性: DN02 has (1 nM-100 μM) low nM AlphaScreen with IC 50 value of 48 nM, with high selectivity over BRD9 and BRD4 in biochemical AlphaScreen assays [1]. DN02 (32 nM) has minimal off-target engagement across the bromodomain family, with modest activity against CBP/P300 [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途