化合物ARQ 621 T6393

Product Introduction
Bioactivity


英文名: ARQ 621

描述: ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂，具有抗肿瘤活性。

体外活性: ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells. [1]

体内活性: ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. [1]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 93 mg/mL (168.3 mM)
DMSO : 93 mg/mL (168.3 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: motor | ARQ 621 | inhibit | cell | division | ARQ621 | protein | Inhibitor | microtubule | Kinesin | Anti-tumor | Eg5 | ARQ-621

相关产品: Paprotrain | Mps1-IN-3 | Betamethasone 17-benzoate | SB-743921 hydrochloride | TC-Mps1-12 | (S)-Monastrol | GSK-923295 | Eg5-IN-1 | EMD534085 | UMK57

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途