盐酸贝西沙星 T6406

Product Introduction
Bioactivity


英文名: Besifloxacin Hydrochloride

描述: Besifloxacin Hydrochloride (BOL-303224-A) 是一种氟喹诺酮类抗生素。

激酶实验: 20 ng of purified human DDK, together with increasing concentrations of each DDK inhibitor is pre-incubated for 5 min. Then 10 μCi (γ)-32P ATP and 1.5 μM cold ATP are added in a buffer containing 50 mM Tris-HCl (pH 7.5), 10 mM MgCl2, and 1 mM DTT and incubated for 30 min at 30°C. The proteins are denatured in 1X Laemmli buffer at 100°C followed by SDS-PAGE and autoradiography on HyBlot CL film. DDK kinase activity is indicated by Auto-phosphorylation of DDK. 32P-labeled bands are quantified using ImageJ and the IC50 values are calculated using GraphPad.

体外活性: Besifloxacin has effectively bactericidal activity against prevalent and drug-resistant pathogens. Besifloxacin is the most potent agent tested against gram-positive pathogens and anaerobes and is generally equivalent to comparator fluoroquinolones in activity against most gram-negative pathogens. Besifloxacin demonstrates potent, broad-spectrum activity, which is particularly notable against gram-positive and gram-negative isolates that are resistant to other fluoroquinolones and classes of antibacterial agents.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11 mg/mL (25.56 mM)


关键字: Besivance Hydrochloride | Antibiotic | Besifloxacin | Bacterial | Besifloxacin Hydrochloride | Inhibitor | inhibit

相关产品: Sofalcone | Benzydamine hydrochloride | Sisomicin Sulfate | Furagin | 6-Amino-5-azacytidine | Cefazolin | 7-Aminocephalosporanic acid | (+)-Usnic acid | Hexylresorcinol | Lonicerin

相关库: Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Bacterial Compound Library | Anti-Viral Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途