(OC-6-44)-三羰基氯(甘氨酸基)钌 T6454

Product Introduction
Bioactivity


英文名: CORM-3

描述: CORM-3 是一种 CO 释放分子，能够减少 NLRP3炎症小体的激活，可以减弱 NF-κB p65的核异位，减少 ROS 的生成，并提高细胞内谷胱甘肽和超氧化物歧化酶的水平。

体外活性: CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]

体内活性: CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]

存储条件: store at low temperature,store under nitrogenPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (169.72 mM)


关键字: inhibit | Inhibitor | CORM 3 | Nuclear factor-kappaB | Nuclear factor-κB | NF-κB | NOD-like Receptor (NLR) | CORM-3

相关产品: Berbamine dihydrochloride | DB1976 dihydrochloride | Tyloxapol | 4beta-Hydroxywithanolide E | Oxaprozin | Phellodendrine | Sanggenone H | Engeletin | BI-69A11 | Pinocembrin

相关库: Antioxidant Compound Library | Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Liver Cancer Compound Library | Pyroptosis Compound Library | Anti-Lung Cancer Compound Library | Ferroptosis Compound Library | Anti-Ovarian Cancer Compound Library | NO PAINS Compound Library | Bioactive Compound Library

(OC-6-44)-三羰基氯(甘氨酸基)钌 T6454信息由TargetMol中国为您提供，如您想了解更多关于(OC-6-44)-三羰基氯(甘氨酸基)钌 T6454报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途