依他普仑草酸盐 T6493

Product Introduction
Bioactivity


英文名: Escitalopram Oxalate

描述: Escitalopram Oxalate ((S)-(+)Citalopram oxalate) 是一种外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂，Ki=0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性，是一种研究抑郁症的抗抑郁药。

体外活性: Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 20.7 mg/mL (50 mM)
DMSO : 41.4 mg/mL (100 mM)


关键字: reuptake | Citalopram Oxalate | Escitalopram Oxalate | impairments | selectivity | antidepressant | inhibit | SLC6A4 | Inhibitor | cognitive | 5-HTT | SERT | depression | Escitalopram | S-enantiomer | Serotonin Transporter | (S)-Citalopram

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相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Angiogenesis related Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途