氟米龙醋酸酯 T6503

Product Introduction
Bioactivity


英文名: Fluorometholone Acetate

描述: Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性，可用于研究外部眼部炎症。

体外活性: Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1]

体内活性: Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 84 mg/mL (200.71 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: Inhibitor | Carbonate dehydratase | Fluorometholone | Fluorometholone Acetate | hCA-II | Carbonic Anhydrase | anti-inflammatory | NSC47438 | corticosteroid | inhibit | NSC-47438 | Cornea | Oxylone Acetate | glucocorticoid | hCA-I

相关产品: Beclometasone | Vamorolone | Finerenone | Fluorometholone | Dexamethasone | Clobetasone butyrate | Hydrocortisone acetate | Cortisone | Relacorilant | AZD5423

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Metabolism Disease Compound Library | Inhibitor Library | Nuclear Receptor Compound Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途