化合物Golgicide A T6516

Product Introduction
Bioactivity


英文名: Golgicide A

描述: Golgicide A 可抑制柯萨奇病毒 B3 和其他人类肠道病毒的复制。它是一种高度特异性可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子抑制剂。

体外活性: Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. [1] Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells. [2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 14.2 mg/mL (50 mM)


关键字: Enterovirus | Rhinovirus | HEVs | HRVs | HEV | GCA | inhibit | Inhibitor | Golgicide A | HRV

相关产品: AZ960 | SARS-CoV-2 3CLpro-IN-15 | QL-X-138 | NS2B-NS3pro-IN-1 | ZINC03129319 | MOSLOFLAVONE | Retro-2 cycl | Lycorine hydrochloride | Aloperine | Trachelogenin

相关库: Bioactive Compounds Library Max | Inhibitor Library | Anti-Viral Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途