磷酰胺二钠 T6627

Product Introduction
Bioactivity


英文名: Phosphoramidon Disodium

描述: Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM。

体外活性: Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. [1] Phosphoramidon reduces tumor cell invasion in CC531 cells. [2]

体内活性: In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. [2] Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD). [3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 169.9 mM
DMSO : 169.9 mM


关键字: Neprilysin | Inhibitor | Phosphoramidon Disodium | NEP | CD10 | Angiotensin-converting Enzyme (ACE) | Phosphoramidon | Neutral endopeptidase | Cluster of differentiation 10 | inhibit

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