盐酸罗格列酮 T6646

Product Introduction
Bioactivity


英文名: Rosiglitazone hydrochloride

描述: Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。

体外活性: Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 73 mg/mL (185.3 mM)
DMSO : 73 mg/mL (185.3 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: mellitus | hepatocellular | PPAR | antihyperglycemic | Inhibitor | cancer | senescence | Rosiglitazone | PPARγ | BRL-49653 | HCC | Apoptosis | diabetic | carcinoma | BRL49653 | bladder | neuroprotection | Rosiglitazone hydrochloride | BRL 49653 | Rosiglitazone Hydrochloride | Autophagy | diabetes | TRP Channel | ovarian cancer | smoke | inhibit | Ferroptosis | Transient receptor potential channels | Peroxisome proliferator-activated receptors

相关产品: DL-Buthionine-(S,R)-sulfoximine | Baicalein | Eugenol | Vildagliptin | L-Glutamine | SRS16-86 | Pioglitazone | SRS11-92 | Lepadin H | BAY 87-2243

相关库: Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Metabolism Disease Compound Library | Ferroptosis Compound Library | Inhibitor Library | Anti-Diabetic Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途