化合物T0070907 T6689

Product Introduction
Bioactivity


英文名: T0070907

描述: T0070907 是一种有效且特异性的 PPARγ 抑制剂，Ki 值为1 nM，其选择性比 PPARα 和 PPARδ 高 800 倍以上。

细胞实验: MTS assay(Only for Reference)

激酶实验: Ligand Binding Assay: To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90-μl reaction contains SPA buffer (10 mm KH2PO4, 10 mm KH2PO4, 2 mm EDTA, 50 mm NaCl, 1 mm dithiothreitol, 2 mmCHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPARγ (or 150 ng of GST-PPARα, GST-PPARδ), 5 nm 3H-labeled radioligands, and 5 μl of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μl of polylysine-coated SPA beads (at 20 mg/ml in SPA buffer) are added, and the mixtureis incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPARγ, and [3H]GW2433 is used for PPARα and PPARδ.

体内活性: T0070907能够减弱脂多糖预处理的有益效果，例如显著改善肾功能不全，减少肝细胞损伤和循环衰竭，并降低由严重内毒素血症引起的血浆白细胞介素-1升高。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (180.08 mM)
1eq. HCl : 27.8 mg/mL (100 mM)


关键字: PPAR | inhibit | T 0070907 | Inhibitor | T-0070907 | Peroxisome proliferator-activated receptors | T0070907

相关产品: Pirinixic Acid | MK-886 | Oleoylethanolamide | Licarin B | Tagitinin A | Peliglitazar racemate | Furegrelate sodium | MA-0204 | PPAR agonist 1 | Oleuropein

相关库: Anti-Aging Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Compound Library | Toxic Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Highly Selective Inhibitor Library | Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途