(E/Z)-4-羟基他莫昔芬 T6743

Product Introduction
Bioactivity


英文名: (E/Z)-4-Hydroxytamoxifen

描述: (E/Z)-4-Hydroxytamoxifen (Afimoxifene) 是 tamoxifen 的活性代谢物和选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。

细胞实验: Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz.

动物实验: Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration

体外活性: 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 71 mg/mL (183.2 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: (E/Z)4Hydroxytamoxifen | Inhibitor | inhibit | (E/Z) 4 Hydroxytamoxifen | Endogenous Metabolite | Estrogen Receptor/ERR | (E/Z)-4-Hydroxytamoxifen

相关产品: Dihydroresveratrol | Amcenestrant | Endoxifen Z-isomer hydrochloride | Y134 | DY131 | Enclomiphene citrate | ERα degrader 6 | Estrogen receptor modulator 7 | Estrogen receptor modulator 10 | Camizestrant TFA

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Human Metabolite Library | Anti-Ovarian Cancer Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途