化合物6-Thio-dG T6746

Product Introduction
Bioactivity


英文名: 6-Thio-2'-Deoxyguanosine

描述: 6-Thio-2'-Deoxyguanosine (β-TGdR) 是一种核苷类似物和端粒酶底物，可以通过端粒酶掺入重新合成的端粒中。

细胞实验: Cells are plated in growth media in 96-well plates. Cells are incubated for 1 week and treated with varying concentrations of 6-thio-dG and 6-thioguanine or DMSO every 3 days. The 96-well plates are analyzed according the manufacturer's directions for the CellTiterGlo luminescent cell viability assay to obtain IC50 values. The IC50 is defined as the concentration of drug at which 50% of the cells are inhibited by the drug. Sigmoidal dose–response curves are used to calculate IC50 values. All samples are analyzed in triplicate, and SDs are from two independent experiments.(Only for Reference)

体外活性: 6-Thio-dG induces telomere dysfunction and results in progressive telomere shortening in telomerase-positive human cancer cells and hTERT-expressing human fibroblasts. In tested cancer cells, 6-thio-dG inhibits cell viability with IC50 values between 0.7 and 2.9 μM. [1]

体内活性: In mice bearing A549 lung cancer xenografts, 6-Thio-dG (2 mg/kg, i.p.) decreases the tumorigenicity of A549 Cells by inducing telomere dysfunction. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 52 mg/mL (183.5 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: Inhibitor | beta-TGdR | inhibit | DNA/RNA Synthesis | b-TGdR | 6Thio2'Deoxyguanosine | 6-Thio-2'-Deoxyguanosine | 6 Thio 2' Deoxyguanosine

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相关库: Nucleotide Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Preclinical Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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