阿替美唑 T6766

Product Introduction
Bioactivity


英文名: Atipamezole

描述: Atipamezole (Antisedan) 是 α2-肾上腺素受体拮抗剂，Ki=1.6 nM。

体外活性: The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].

体内活性: Atipamezole is well tolerated in rodents. The cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest in anesthetized, normotensive rats. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals while not necessarily on short-term working memory[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 39 mg/mL (183.7 mM)
Ethanol : 39 mg/mL (183.7 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: Adrenergic Receptor | Beta Receptor | MPV1248 | MPV-1248 | Inhibitor | inhibit | Atipamezole

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