化合物MCT1-IN-3 T67727

Product Introduction
Bioactivity


英文名: MCT1-IN-3

描述: MCT1-IN-3是一种单羧酸转运蛋白1 (MCT1)抑制剂。溶质载体(SLC)单羧酸转运蛋白1 (MCT1);SLC16A1)是治疗癌症的一个有希望的靶点。MCT1-IN-3(化合物24)对MCT1转运抑制作用强，IC50值为81.0 nM。MCT1-IN-3对多药转运体ABCB1也有明显的抑制作用。

体外活性: MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (57.78 mM)


关键字: MCT1IN3 | MCT1-IN-3

相关产品: Niflumic acid | 7ACC1 | AZD0095 | α-Cyano-4-hydroxycinnamic acid | D-Phenylalanine | VB124 | Lactate transportor 1 | 7ACC2 | AZD3965 | BAY-8002

相关库: Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途