Tubulin抑制剂11 T67935

Product Introduction
Bioactivity


英文名: Tubulin inhibitor 11

描述: Tubulin inhibitor 11 是一种口服活性的有效微管蛋白抑制剂。它通过靶向秋水仙碱结合位点，抑制tubulin聚合，进而促进有丝分裂阻断和apoptosis。

体外活性: Swainsonine (0-40 μM ; 12 h) showed anti-proliferative activity in U251 and LN444 cells.[2] Swainsonine (30 μM ; 12 h) induced apoptosis and cell cycle arrest in G2/M phase and decreased the expression of CyclinD1 and CDK4 protein levels and increased the expression of p16 protein level.[2] Swainsonine (30 μM ; 12 h) reduces glioma cell migration and invasion.[2]

体内活性: Swainsonine (1 mg/kg ; intraperitoneal injection ; twice daily for 10 days) and cisplatin increased the antitumor efficacy in mice.[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (219.8 mM)


关键字: CompoundTubulininhibitor11 | Tubulin inhibitor 11

相关产品: RUNX-IN-2 | 1,4-Dideoxy-1,4-epithio-D-ribitol | Demethylzeylasteral | CHM-1 | Diclofenac sodium | Chelidonine | Aristolactam I | AEE788 | Triciribine phosphate | Parthenolide

相关库: Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Bioactive Compound Library

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