化合物 IRC-083927 HCl T68249
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 955082-09-4 | ¥10,600.00 | 询底价 |
50 mg | 955082-09-4 | ¥13,800.00 | 询底价 |
100 mg | 955082-09-4 | ¥17,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: IRC-083927 HCl
描述: IRC-083927 HCl is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two human tumor xenografts in nude mice (C33-A, human cervical cancer and MDA-MB-231, human hormone-independent breast cancer). Together, the antitumor effects induced by IRC-083927 on tumor models resistant to tubulin agents support further investigations to fully evaluate its potential for the treatment of advanced cancers, particularly those resistant to current clinically available drugs.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: IRC 083927 | IRC-083927 hydrochloride | IRC-083927 HCl | IRC-083927
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途