谷氨酸单钠盐 T6871

Product Introduction
Bioactivity


英文名: L-Glutamic acid monosodium salt

描述: L-Glutamic acid monosodium salt (MSG) 作为兴奋性氨基酸神经递质，是谷氨酸盐受体所有亚型的激动剂，对多巴胺从神经末梢释放的过程有激动作用。

细胞实验: B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining. (Only for Reference)

体外活性: Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in na?ve B cells compared to memory B cell population[3]. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro[4].

体内活性: Daily monosodium glutamate(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis[1]. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : < 1mg/ml (insoluble）


关键字: L-Glutamic acid | Endogenous Metabolite | Inhibitor | Apoptosis | inhibit | LGlutamic acid monosodium salt | Ferroptosis | L-Glutamic acid monosodium | Ionotropic glutamate receptors | L Glutamic acid monosodium salt | iGluR

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相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Cell Cycle Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Food Additive Library | Neuronal Signaling Compound Library | Human Metabolite Library | Ferroptosis Compound Library | Anti-Cancer Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途