盐酸普拉格雷 T6952

Product Introduction
Bioactivity


英文名: Prasugrel Hydrochloride

描述: Prasugrel Hydrochloride (LY 640315 Hydrochloride) 是一种噻吩吡啶和前药，是一种可口服的P2Y12受体拮抗剂，抑制 ADP 诱导的血小板聚集，用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞，以及接受经皮冠状动脉介入治疗的患者。

体内活性: Prasugrel significantly inhibits arterio-venous (AV) shunt and electrically induced arterial thrombosis in single dose ranges of 0.3 to 3 mg/kg and of 0.3 and 1 mg/kg/day for multiple doses. These doses are similar to doses with inhibition of platelet activation via P2Y12 receptors, suggesting that the protective effects of prasugrel in these cerebral infarction and peripheral arterial occlusive disease models reflect P2Y12 inhibitions on platelets by prasugrel's active metabolite. Prasugrel also significantly prevents progression of peripheral vascular lesions[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 43 mg/mL (104.9 mM)
Ethanol : 9 mg/mL (21.95 mM)


关键字: LY640315 | aggregation | platelet | Inhibitor | PCR-4099 | P2Y Receptor | antiplatelet | LY-640315 Hydrochloride | ADP | PCR 4099 | active | PCR4099 | metabolite | LY640315 Hydrochloride | Prasugrel Hydrochloride | inhibit | LY-640315 | Prasugrel

相关产品: Clopidogrel hydrogen sulfate | AZD1283 | MRS 2578 | BPTU | Diquafosol tetrasodium | Ticagrelor metabolite M5 | Uridine-5'-diphosphate disodium salt | Prasugrel | Ticagrelor | (±) Clopidogrel hydrogen sulfate

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | Orally Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途