甲磺酸雷沙吉兰 T6962
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 161735-79-1 | ¥671.00 | 询底价 |
500 mg | 161735-79-1 | ¥1,675.00 | 询底价 |
25 mg | 161735-79-1 | ¥253.00 | 询底价 |
50 mg | 161735-79-1 | ¥418.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Rasagiline Mesylate
描述: Rasagiline Mesylate (AGN1135) 是一种高效的,不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂,抑制大鼠脑 MAO B 和 MAO A 的IC50分别为 4.43 nM 和 412 nM。
体外活性: Rasagiline inhibits rat brain MAO type B and type A with IC50 of 4.43 nM and 412 nM, respectively. Rasagiline is three to 15 times more potent than selegiline for inhibition of MAO-B in rat brain and liver in vivo on acute and chronic administration, but has similar potency in vitro. [1] Rasagiline prevents nuclear accumulation of GAPDH induced by N-methyl(R) salsolinol in SH-SY5Y cells. Rasagiline prevents the collapse in ΔΨm, and following apoptotic process, which indicates that mitochondria may determine the survival and death of the cells. [2] Rasagiline has potent antiapoptotic and neuroprotective activities in response to serum and NGF withdrawal in partially neuronally differentiated PC12 cells and prevents the fall in mitochondrial membrane potential, the first step in cell death. [3] Rasagiline is metabolized to its major metabolite aminoindan, selegiline gives rise to L-methamphetamine. Rasagiline directly activates PKC-MAP kinase pathway by a concentration and time dependent phosphorylation of p42 and p44 MAP kinase. [4]
体内活性: Rasagiline ex vivo inhibits MAO in the brain and liver with ED50 of 4.43 nM and 412 nM, respectively. [1] Rasagiline (0.2 mg/kg and 1 mg/kg) accelerates the recovery of motor function and spatial memory and reduces the cerebral oedema by about 40-50% in the mouse. [5]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 93.51mM
DMSO : 60 mg/mL (224.43 mM)
关键字: Rasagiline | Rasagiline Mesylate | inhibit | Monoamine Oxidase | Apoptosis | MAO | AGN 1135 | AGN-1135 | Inhibitor | (R)-AGN1135 | Autophagy | TVP 1012 | TVP-1012
相关产品: Picropodophyllin | XL019 | Periplocin | Mebendazole | Dp44mT | AT7519 Hydrochloride | Tauroursodeoxycholate sodium | Chlorhexidine digluconate | Phenoxodiol | Diatrizoic Acid
相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Parkinson's Disease Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途