化合物 EGIS-8332 T69806

Product Introduction
Bioactivity


英文名: EGIS-8332

描述: EGIS-8332 is a potent and selective non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA/kainate ion channels and cell death. EGIS-8332 inhibited AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC(50)=5.1-9.0 microM), in vitro. EGIS-8332 seems suitable for further development for the treatment of epilepsy, ischaemia and stroke based on its efficacy in a variety of experimental disease models, and on its low side effect potential.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: EGFRIN451 | EGFR inhibitor 451 | EGIS8332 | EGIS-8332 | EGIS 8332 | EGFR-inhibitor-451 | EGFR IN 451

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途