苯并[a]芘 T6985
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 50-32-8 | ¥919.00 | 询底价 |
1 mL | 50-32-8 | ¥462.00 | 询底价 |
200 mg | 50-32-8 | ¥3,792.00 | 询底价 |
100 mg | 50-32-8 | ¥1,997.00 | 询底价 |
10 mg | 50-32-8 | ¥417.00 | 询底价 |
500 mg | 50-32-8 | ¥4,940.00 | 询底价 |
50 mg | 50-32-8 | ¥1,378.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Benzo[a]pyrene
描述: Benzo[a]pyrene (3,4-Benzopyrene) 在动物模型中显示肺致癌性,可用于化学预防研究。
动物实验: After a 1- or 2-week acclimatization period, 360 adult male A/J mice and 520 adult female A/J mice were used for the experiment.?Mice were allocated, using a body weight-based randomization process, to a total of 22 groups.?Briefly, each animal received a single intraperitoneal administration of one of the initiators, at one of the indicated doses, on day 1.?The animals were observed daily for clinical signs and mortality, and body weights were measured weekly.?Following an overnight fast at 26 weeks after dosing, all mice were anesthetized with sevoflurane and weighed.?They were then sacrificed by exsanguination from the abdominal aorta and caudal vena cava and subjected to necropsy[1].
体内活性: lung tumorigenesis induced by Benzo[a]pyrene(B[a]P) was dose dependent in female A/J mice.?The incidence of hyperplasia values in females treated with 0.25, 0.50, and 1.0 mg B[a]P were significantly higher than in the vehicle-treated group.?The incidence of adenoma in females receiving 1.0 mg B[a]P was significantly higher than in the vehicle group.?The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg B[a]P was significantly higher than in the vehicle group.?The multiplicity of adenoma in the group treated with 1.0 mg was also significantly higher than in the vehicle group.?The incidences of hyperplasia and adenoma in female A/J mice were significantly increased by B[a]P in a dose-dependent manner.?Proliferative lesions in the lungs were classified as bronchiolar-alveolar hyperplasia or adenoma, and no malignant neoplasms (adenocarcinoma) were observed[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 9.09 mg/mL (36.03 mM )
关键字: Inhibitor | Endogenous Metabolite | inhibit | Benzo[a]pyrene
相关库: Bioactive Compounds Library Max | Human Metabolite Library | Mouse Metabolite Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途