化合物SKF38393 HCl T6988

Product Introduction
Bioactivity


英文名: SKF 38393 hydrochloride

描述: SKF 38393 hydrochloride (SKF38393 HCl) 是选择性的多巴胺 D1 受体激动剂，IC50=110 nM。

体外活性: SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]

体内活性: SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 6 mg/mL(20.56 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 54 mg/mL (185.1 mM)


关键字: SKF 38393 Hydrochloride | SKF 38393 | SKF-38393 | SKF 38393 hydrochloride | inhibit | Inhibitor | SKF38393 | SKF38393 Hydrochloride | SKF-38393 Hydrochloride | Dopamine Receptor

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相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Antidepressant Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Anti-Cancer Active Compound Library | Preclinical Compound Library

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