牛磺熊去氧胆酸钠 T6993
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 35807-85-3 | ¥206.00 | 询底价 |
1 mL | 35807-85-3 | ¥160.00 | 询底价 |
100 mg | 35807-85-3 | ¥629.00 | 询底价 |
50 mg | 35807-85-3 | ¥371.00 | 询底价 |
500 mg | 35807-85-3 | ¥1,263.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Tauroursodeoxycholate sodium
描述: Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK,显著降低凋亡分子表达,如caspase-3和caspase-12。
细胞实验: Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.
动物实验: Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection
体内活性: In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 10 mg/mL(19.2 mM)
DMSO : 55 mg/mL (105.43 mM)
H2O : 92 mg/mL (176.3 mM)
关键字: molecules | UR-906 | Caspase | UR 906 | Extracellular signal regulated kinases | reticulum | caspase-3 | Inhibitor | endoplasmic | Apoptosis | Tauroursodeoxycholic acid | TUDCA | stress | UR906 | Tauroursodeoxycholic acid sodium | Tauroursodeoxycholate sodium | caspase-12 | inhibit | ERK | Sodium Tauroursodeoxycholate | Tauroursodeoxycholate
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相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Protease Inhibitor Library | Stem Cell Differentiation Compound Library | MAPK Inhibitor Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途