化合物 JTP-4819 T70365
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 162203-65-8 | ¥17,500.00 | 询底价 |
25 mg | 162203-65-8 | ¥10,600.00 | 询底价 |
50 mg | 162203-65-8 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: JTP-4819
描述: JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentration, JTP-4819 inhibited the degradation of substance P, arginine-vasopressin, and thyrotropin-releasing hormone by PEP in supernatants of the rat cerebral cortex and hippocampus. Repeated administration of JTP-4819 reversed the aging-induced decrease in brain substance P-like and thyrotropin-releasing hormone-like immunoreactivity, suggesting that this drug may be able to improve the imbalance of peptidergic neuronal systems that develops with senescense by inhibiting PEP activity. JTP-4819 increased acetylcholine release from the frontal cortex and hippocampus, regions closely associated with memory, in both young and aged rats.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: JTP-4819 | JTP 4819 | PF 06663195 | PF06663195 | JTP4819
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途