化合物 YM-543 choline T70390

Product Introduction
Bioactivity


英文名: YM-543 choline

描述: YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose levels and improved glucose tolerance with a concomitant increase in urinary glucose excretion in KK/Ay type 2 diabetic mice, effects that were sustained even after 12 h.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: ARRY-403 | AMG-151 | ARRY 403 | AMG151 | YM-543 choline | ARRY403 | AMG 151 | AMG-151 hydrochloride

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途