化合物 AMG151 HCl T70391
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1609674-80-7 | ¥15,000.00 | 询底价 |
50 mg | 1609674-80-7 | ¥19,800.00 | 询底价 |
100 mg | 1609674-80-7 | ¥25,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: AMG151 HCl
描述: ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesses good in vitro drug-like properties (aqueous solubility, cell permeability, low low potential for drug-drug interactions, low predicted hepatic clearance), and selectivity against broad panels of receptors and enzymes.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Tyrphostin AG 808 | AMG151 HCl | Tyrphostin AG808
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途