化合物 AZ5576 racemate T70953
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1333468-05-5 | ¥13,800.00 | 询底价 |
25 mg | 1333468-05-5 | ¥10,600.00 | 询底价 |
100 mg | 1333468-05-5 | ¥17,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: AZ5576 racemate
描述: AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: AZ5576 racemate | Ro-09-1450 | Ro-091450 | SPF-30595 | SPF 3059-5 | SPF-3059-5 | Ro 091450 | SPF30595 | Ro 09-1450 | SPF 30595 | Ro09-1450 | SM-345431 | SM 345431 | Ro091450 | SM345431 | SPF3059-5
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途