化合物 MPT0B214 T71217
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1215208-65-3 | ¥13,800.00 | 询底价 |
100 mg | 1215208-65-3 | ¥17,500.00 | 询底价 |
25 mg | 1215208-65-3 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: MPT0B214
描述: MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of the mitotic marker MPM-2. Furthermore, the compound induced apoptotic cell death through mitochondria/caspase 9-dependent pathway. Notably, several KB-derived multidrug-resistant cancer cell lines were also sensitive to MPT0B214 treatment. ( PLoS One. 2013;8(3):e58953).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MPT0B-214 | S11566 | MPT0B 214 | MPT0B214 | S-11566
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途