化合物 GNF-8625 T71267
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1196546-33-4 | ¥10,600.00 | 询底价 |
50 mg | 1196546-33-4 | ¥13,800.00 | 询底价 |
100 mg | 1196546-33-4 | ¥17,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: GNF-8625
描述: GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal, papillary thyroid, glioblastoma, melanoma, and lung tissue that are believed to be the key oncogenic driver in these tumors.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: GNF 8625 | ASP 7657 | ASP7657 | GNF-8625 | GNF8625
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途