化合物Purvalanol B T7167

Product Introduction
Bioactivity


英文名: Purvalanol B

描述: Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。

动物实验: A SYBR Green I parasite growth assay was used to measure the IC50 of Purvalanol B with P. falciparum (strain W2). Purvalanol B or DMSO control were applied to synchronized parasites 36 hours post invasion and parasites were incubated for 12 hours. Giemsa-stained blood smears were used to determine the effect of Purvalanol B on parasite growth, global quantitative proteomic analysis was used to examine differences in protein expression between Purvalanol B-treated and control parasites and results were confirmed by qPCR[1].

体内活性: Purvalanol B application decreases the ability of late-stage P.falciparum trophozoites to form multinucleated schizonts and up-regulates proteasome subunits and proteins that contribute to redox homeostasis, which may indicate an increase in oxidative stress as a result of inhibitor application[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (92.40 mM)


关键字: cdc2 | inhibit | cyclin | CDK2 | NG95 | CDK5 | Purvalanol B | CDK | Parasite | NG-95 | P. falciparum | ATP | Cyclin dependent kinase | Inhibitor | p35

相关产品: ML167 | CDK12-IN-2 | CDK2-IN-20 | Pinoresinol | PF-562271 besylate | GW779439X | CDK4/6-IN-2 | Avotaciclib | AZ1495 | PROTAC CDK9 Degrader-1

相关库: Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Parasitic Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途