辣椒平 T7177

Product Introduction
Bioactivity


英文名: Capsazepine

描述: Capsazepine 是一种 TRPV1 受体的拮抗剂， IC50值为 562 nM。 它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感，是辣椒素拮抗剂。

体内活性: Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1.?Capsazepine can exhibit diverse effects on cancer (prostate cancer, breast cancer, colorectal cancer, oral cancer, and osteosarcoma) growth and survival, and can be therapeutically used against other major disorders such as colitis, pancreatitis, malaria, and epilepsy.?Capsazepine has been reported to exhibit pleiotropic anti-cancer effects against numerous tumor cell lines.?Capsazepine can modulate Janus activated kinase (JAK)/signal transducer and activator of the transcription (STAT) pathway, intracellular Ca2+ concentration, and reactive oxygen species (ROS)-JNK-CCAAT/enhancer-binding protein homologous protein (CHOP) pathways.?It can inhibit cell proliferation, metastasis, and induce apoptosis.?Moreover, capsazepine can exert anti-inflammatory effects through the downregulation of lipopolysaccharide (LPS)-induced nuclear transcription factor-kappa B (NF-κB), as well as the blockage of activation of both transient receptor potential cation channel subfamily V member 1 (TRPV1) and transient receptor potential cation channel, subfamily A, and member 1 (TRPA1)[1].

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (132.66 mM)


关键字: Apoptosis | Capsazepine | Transient receptor potential channels | TRP Channel | Inhibitor | inhibit

相关产品: Raddeanin A | 6-Thioguanine | AMAROGENTIN | Acacetin | Bz 423 | Riviciclib hydrochloride | Delanzomib | Epibrassinolide | HS-173 | Diatrizoic Acid

相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Chinese Pharmacopoeia Natural Product Library | Human Metabolite Library | Inhibitor Library | Apoptosis Compound Library | Natural Product Library for HTS | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途