盐酸舒必利 T7180

Product Introduction
Bioactivity


英文名: Sultopride hydrochloride

描述: Sultopride hydrochloride (LIN-1418 hydrochloride) 是一种多巴胺 D2受体的选择性拮抗剂。

体内活性: Sultopride and sulpiride are both chemically similar benzamide derivatives and selective antagonists of dopamine D2 receptors.?However, these drugs differ in clinical properties.?We compared the effects of sultopride and sulpiride on dopamine turnover in rats following the administration of these drugs alone or in combination with apomorphine.?The administration of sultopride or sulpiride markedly accelerated dopamine turnover in the rat brain.?The increase in the level of dopamine metabolites in the striatum was more marked in the sultopride-treated rats.?Sulpiride affected the limbic dopamine receptors preferentially, whereas sultopride affected the striatal and the limbic dopamine receptors equally.?A low dose of apomorphine induced a reduction in the concentration of dopamine metabolites in the striatum and the nucleus accumbens by approximately 55%, but not in the medial prefrontal cortex.?Sultopride was more effective in preventing an apomorphine-induced reduction in dopamine metabolite levels.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (127.90 mM)


关键字: dopamine | Sultopride | Sultopride hydrochloride | Dopamine Receptor | LIN 1418 Hydrochloride | LIN-1418 | LIN 1418 | HVA | LIN1418 | Inhibitor | striatum | LIN1418 Hydrochloride | LIN-1418 Hydrochloride | receptor | inhibit | DOPAC | Sultopride Hydrochloride | levels

相关产品: Zotepine | PF2562 | SB-277011 | 9-FLUORENOL | 5-Benzyloxygramine | Desmethyl cariprazine | Diclofensine hydrochloride | 5-HT6/7 antagonist 1 | Trifluoperazine | (Rac)-Rotigotine hydrochloride

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-COVID-19 Compound Library | ReFRAME Related Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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