化合物A 967079 T7205
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1170613-55-4 | ¥530.00 | 询底价 |
25 mg | 1170613-55-4 | ¥1,650.00 | 询底价 |
1 mg | 1170613-55-4 | ¥218.00 | 询底价 |
10 mg | 1170613-55-4 | ¥755.00 | 询底价 |
100 mg | 1170613-55-4 | ¥4,290.00 | 询底价 |
50 mg | 1170613-55-4 | ¥2,910.00 | 询底价 |
5 mg | 1170613-55-4 | ¥485.00 | 询底价 |
Product Introduction
Bioactivity
英文名: A-967079
描述: A 967079是一种有效的TRPA1受体选择性拮抗剂,对人和大鼠 TRPA1 受体的IC50分别为 67 nM 和 289 nM。A 967079具有良好的CNS 穿透性。
动物实验: Separated by 5 min each, to specific stimulation of the neuronal RF were recorded. Spontaneous and evoked neuronal activity was then measured 5, 15, 25, and 35 min after systemic injection of A-967079 (30 μmol/kg) or vehicle (polyethylene glycol). The intravenous injection of A-967079 or vehicle was completed over a 6-7 min period. The i.v. dose of A-967079 was selected based on extrapolated plasma levels that were effective in behavioral studies . Except for 2 experiments in which two easily distinguished neurons were simultaneously recorded on one electrode, only one neuron was studied per rat. Since only one vehicle was used in these experiments, vehicle data was combined when a clear "no effect' was observed in at least 2-3 animals from a particular subset of groups (OA and sham OA)[1].
体内活性: Systemic injection of A 967079 (30 micromol/kg) decreased the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation of the ipsilateral hind paw in uninjured and CFA-inflamed rats. Similarly, A-967079 reduced the responses of WDR neurons to high-intensity mechanical stimulation (300 g von Frey hair) of the knee joint in both OA and OA-sham rats. WDR neuronal responses to low-intensity mechanical stimulation (10 g von Frey hair) were also reduced by A-967079 administration to CFA-inflamed rats, but no effect was observed in uninjured rats. Additionally, the spontaneous activity of WDR neurons was decreased after A-967079 injection in CFA-inflamed rats but was unaltered in uninjured, OA, and OA-sham animals[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (482.53 mM)
关键字: TRP Channel | inhibit | Transient receptor potential channels | A967079 | A 967079 | A-967079 | Inhibitor
相关产品: JT010 | Piromelatine | (+)-Camphor | SB-366791 | HC067047 Hydrochloride(883031-03-6 free base) | RQ-00203078 | ML329 | ABT-239 | Methyl Kakuol | Englerin A
相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | CNS-Penetrant Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途