R 59-022 盐酸盐 T72322

Product Introduction
Bioactivity


英文名: R 59-022 hydrochloride

描述: R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。

体外活性: R 59-022 (10 μM; 1 min) Hydrochloride enhances platelet aggregation.[1]R 59-022 (30 μM; 0-60 min) Hydrochloride increases the release of norepinephrine in chromaffin cells.[2]R 59-022 (40 μM; 30 min) Hydrochloride activates PKC in HeLa and U87 cells.[3]R 59-022 (0-10 μM; 4 h) Hydrochloride blocks the entry of EBOV GP into Vero cells.[4]

体内活性: R 59-022 (2 mg/kg; i.p.; 12 days) significantly increased the median survival of SCID mice implanted with U87 GBM cells.[6]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (110.88 mM)


关键字: R 59-022 Hydrochloride | Diacylglycerol kinase inhibitor I Hydrochloride | DKGI-I Hydrochloride

相关产品: MRS7925 | 1-Hydroxy-2,3,5-trimethoxyxanthone | Cinchonidine | Masupirdine free base | AVN-101 | Onitisin | Lurasidone hydrochloride | H-9 dihydrochloride | ML 10302 hydrochloride | Cannabigerol

相关库: Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Inhibitor Library | Kinase Inhibitor Library | TGF-beta/Smad Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途