化合物ICA-121431 T7336

Product Introduction
Bioactivity


英文名: ICA-121431

描述: ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) 是强效的、广谱的电压门控钠通道阻滞剂，对人 Nav1.1 和 Nav1.3 亚型具有等效选择性，IC50分别为 13 nM 和 23 nM。它对Nav1.2 的抑制作用较弱，IC50为240 nM，对 Nav1.4、Nav1.6、抗TTX 的人 Nav1.5、Nav1.8 通道表现出大于 1000 倍的选择性，IC50>10 μM。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 44 mg/mL (97.88 mM)


关键字: Nav | Na channels | ICA 121431 | inhibitor | TTX-resistant | Sodium Channel | channel | Na+ channels | ICA-121431 | inhibit | ICA121431

相关产品: Vernakalant Hydrochloride | Levobupivacaine hydrochloride | Ethacizine hydrochloride | 6-Benzoylheteratisine | Benzocaine | Phenazopyridine hydrochloride | SYM2206 | Zandatrigine | Tocainide hydrochloride | DSP-2230

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Sodium Channel Blocker Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

化合物ICA-121431 T7336信息由TargetMol中国为您提供，如您想了解更多关于化合物ICA-121431 T7336报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途