对称N,N-二甲基精氨酸 T7344

Product Introduction
Bioactivity


英文名: SDMA

描述: SDMA (Symmetric dimethylarginine) 是一氧化氮 (NO) 合酶的内源性抑制剂。

体外活性: SDMA inhibited dose dependently the NO synthesis in intact endothelial cells, whereas it had no effect on protein expression of NOS. This effect was associated with an increase in reactive oxygen species. Co-incubation with L-arginine but not D-arginine reversed the effect of SDMA on NOS pathway. Suggest that SDMA reduced the endothelial NO synthesis, probably by limiting L-arginine supply to NOS. It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (247.22 mM)


关键字: inhibit | SDMA | Inhibitor | Endogenous Metabolite

相关产品: Betaine chloride | Retinyl palmitate | Caryophyllene oxide | Palmitoylethanolamide | N6-methyladenosine | H-HoArg-OH | Succinic acid | Uridine triphosphate | (S)-b-aminoisobutyric acid | N-Acetylneuraminic acid

相关库: Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Gut Microbial Metabolite Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途