托西溴苄铵 T7386

Product Introduction
Bioactivity


英文名: Bretylium tosylate

描述: Bretylium tosylate 是交感神经和肾上腺素神经的阻断剂，是血管收缩的神经递质突触前释放的抑制剂。

体内活性: Nine patients who had recurrent ventricular fibrillation following acute myocardial infarction or angina were given bretylium tosylate in a dose of 5 mg./kg. intramuscularly every eight hours after other measures had proved ineffective. Provided the patients were not in shock or in heart failure, there was a considerable reduction in the episodes of ventricular fibrillation.A second group of nine patients who developed recurrent ventricular fibrillation following open heart surgery were given bretylium intravenously, which controlled the arrhythmia in every instance.Bretylium did not completely abolish ventricular premature beats but the latter did not initiate ventricular fibrillation even when they occurred on the T wave[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (72.40 mM)


关键字: inhibit | Bretylium Tosylate | Inhibitor | Bretylium | Bretylium tosylate

相关库: Drug Repurposing Compound Library | Approved Drug Library | ReFRAME Related Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | NO PAINS Compound Library | Bioactive Compound Library

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