坦度螺酮柠檬酸盐 T7412

Product Introduction
Bioactivity


英文名: Tandospirone citrate

描述: Tandospirone citrate (SM-3997 citrate) 是一种选择性5-HT1A 受体激动剂，Ki 为27 nM。

细胞实验: In this double-blind, placebo-controlled, multicenter study, FD patients were randomized to treatment with 10 mg t.i.d. tandospirone citrate or to placebo for 4 weeks. The primary end point was change in abdominal symptom scores. The difference in the proportion of responders (a total abdominal symptom score of 0 or 1) was also assessed. The quality-of-life questionnaire, the SF-8, and a psychological test questionnaire, the State-Trait Anxiety Inventory (STAI), were completed at baseline and at weekly intervals[1]

体内活性: Improvements in total abdominal scores were significantly larger with tandospirone than placebo at weeks 1, 2, and 4.?Significantly greater improvements in the tandospirone group were observed in upper abdominal pain (P=0.02) and discomfort (P=0.002) at week 4.?The proportion of responders was significantly greater in the active treatment arm at weeks 3 (P=0.017) and 4 (P=0.0016).?Significant improvements in STAI (P<0.0001) were reported in both arms, as well as in the majority of questions in the SF-8 (P=0.04).?No serious adverse events were reported, with similar rates in both study arms[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10.4 mg/mL (18.07 mM)
DMSO : 50 mg/mL (86.86 mM)


关键字: SM3997 | Tandospirone Citrate | SM-3997 | Tandospirone | SM3997 Citrate | SM-3997 Citrate | Tandospirone citrate | Inhibitor | SM 3997 Citrate | Serotonin Receptor | SM 3997 | 5-hydroxytryptamine Receptor | inhibit | 5-HT Receptor

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途