维汀-格仑妥木单抗 T74178

Product Introduction
Bioactivity


英文名: Glembatumumab vedotin

描述: Glembatumumab vedotin (CDX-011) 是一种抗体活性小分子偶联物，Glembatumumab vedotin 具有强大的抗癌作用，可用于研究三阴性乳腺癌(TNBC)。

体外活性: Glembatumumab vedotin binds to GPNMB on tumor cells, and the complex is internalized. Within the lysosomal compartment, the protein linker containing monomethyl auristatin E (MMAE) is enzymatically cleaved, releasing MMAE. MMAE inhibits microtubules, leading to cell cycle arrest and subsequent tumor cell death[1].Glembatumumab vedotin exhibits cytotoxic activity against osteosarcoma cells at concentrations ranging from 1 to 125 μg/mL over a 96-hour period[2].

体内活性: In human SK-MEL-2 and SK-MEL-5 melanoma xenograft models, Glembatumumab vedotin (CR011-vcMMAE) demonstrates both short-term antitumor effects (inhibiting tumor growth) and long-term effects (complete regression) when administered via intravenous injection at doses ranging from 1.25 to 80 mg/kg, every 4 days, for a duration of 16 days[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

相关产品: CHM-1 | BTB-1 | Tubulysin D | MT189 | Monomethyl auristatin E | Myoseverin | Curvulin | Thiabendazole | Jasplakinolide | MKC-1

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途