4-羟基-L-异亮氨酸 T7448

Product Introduction
Bioactivity


英文名: 4-Hydroxyisoleucine

描述: 4-Hydroxyisoleucine (4-​Hydroxy-​L-​isoleucine) 是从胡芦巴种子中提取和纯化的一种氨基酸，具有促胰岛素作用。

体外活性: 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity.?4-OHIle increases glucose-induced insulin release, and the insulin response mediated by 4-OHIle depends on glucose concentration.?The beneficial effects observed are related to the regulation of blood glucose, plasma triglycerides, total cholesterol, free fatty acid levels, and the improvement of liver function.?The mechanism of action is related to increased Akt phosphorylation and reduced activation of Jun N-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-κB[1].4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Insoluble
H2O : 10 mM


关键字: Inhibitor | 4-Hydroxy-L-isoleucine | inhibit | 4-Hydroxyisoleucine | 4 Hydroxyisoleucine | 4Hydroxyisoleucine

相关库: Anti-Aging Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Glutamine Metabolism Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途