胍基琥珀酸 T7523
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 6133-30-8 | ¥1,497.00 | 询底价 |
50 mg | 6133-30-8 | ¥996.00 | 询底价 |
25 mg | 6133-30-8 | ¥696.00 | 询底价 |
10 mg | 6133-30-8 | ¥397.00 | 询底价 |
1 mL | 6133-30-8 | ¥373.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Guanidinosuccinic acid
描述: Guanidinosuccinic acid 是一种含氮代谢物,在尿毒症患者的血清和尿液中水平升高。
体内活性: Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old.?Epileptogenic and toxic properties were assessed and GSA brain levels following i.p. injection were determined.?In adult mice, GSA induced long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n = 35), and an LD50 of 579 (445-756) mg/kg.?The CD50 of GSA corresponded with a brain concentration of 56 nmol/g tissue.?Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions.?When young mice were i.p. injected with a (for adults) subconvulsive dose of GSA (250 mg/kg), an age-dependent decrease was noted in GSA-induced convulsions and in the resulting brain concentration[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 6 mg/mL (34.26 mM)
DMSO : 75 mg/mL (428.23 mM)
关键字: Guanidinosuccinic acid | Inhibitor | Endogenous Metabolite | inhibit
相关产品: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride | 2,3-Diaminopropionic acid | Trimethylamine N-oxide dihydrate | 5-Hydroxymethyluracil | L-Phenylalanine | 17α-Hydroxyprogesterone | Myricetin | Triolein | Ginsenoside Rf | 2-Methylacetophenone
相关库: Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Gut Microbial Metabolite Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library
胍基琥珀酸 T7523信息由TargetMol中国为您提供,如您想了解更多关于胍基琥珀酸 T7523报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途