牛磺罗定 T7533
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 19388-87-5 | ¥463.00 | 询底价 |
25 mg | 19388-87-5 | ¥195.00 | 询底价 |
500 mg | 19388-87-5 | ¥1,120.00 | 询底价 |
1 mL | 19388-87-5 | ¥99.00 | 询底价 |
50 mg | 19388-87-5 | ¥297.00 | 询底价 |
200 mg | 19388-87-5 | ¥676.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Taurolidine
描述: Taurolidine 是一种广谱抗菌剂,用于预防中心静脉导管相关感染。它具有抗真菌和抗肿瘤作用。
细胞实验: In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1].
动物实验: In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1].
体外活性: Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1].
体内活性: In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (175.83 mM)
关键字: antiseptic | CVC | Inhibitor | inhibit | antimicrobial | catheters | central | CRBSI | catheter-related | Apoptosis | Antibiotic | infections | venous | Bacterial | Taurolidine
相关产品: Prexasertib | Oxcarbazepine | Masitinib mesylate | Notoginsenoside R1 | BAY 11-7082 | SM-164 | MK-4101 | Rabeprazole sodium | Nitroaspirin | Pim-1 kinase inhibitor 4
相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途